2'-O-C22-A(Bz) Phosphoramidite
CAS No. 2923115-67-5

Technical Data of 2'-O-C22-A(Bz) Phosphoramidite

Key Advantages of of 2'-O-C22-A(Bz) Phosphoramidite

Enhanced Stability: 2'-O-C22 (CAS No. 2923115-67-5) modification provides oligonucleotides with resistance to enzymatic degradation, critical for maintaining drug efficacy in biological environments.

Improved Delivery: Hydrophobic properties enable better interaction with delivery vectors, enhancing cellular uptake and bioavailability.

Reduced Immunogenicity: Minimizes immune system activation, ensuring safer therapeutic profiles.

Scalability: Facilitates efficient large-scale synthesis of modified oligonucleotides, supporting commercial drug development.

The Applications of 2'-O-C22-A(Bz) Phosphoramidite

Antisense Oligonucleotide (ASO) Drugs: Used in gene silencing and regulation, particularly for treating genetic disorders, metabolic diseases, and cancer.

Small Interfering RNA (siRNA) Therapies: Applied in RNA interference (RNAi) technology to silence disease-causing genes, targeting conditions such as viral infections, neurodegenerative disorders, and certain cancers.

mRNA-Based Therapeutics: Key in mRNA vaccine development and protein replacement therapies for diseases such as infectious diseases and rare genetic conditions.

Aptamer-Based Drugs: Aptamers are used as targeting agents in therapeutics, especially for oncology and cardiovascular diseases.

CRISPR/Cas9-Based Gene Editing: Facilitates the synthesis of guide RNAs (gRNAs) for precise gene editing in therapies targeting genetic mutations.