2'-OMe-rA(Bz) Phosphoramidite typical modification to increase oligonucleotide stability and strengthen resistance to nuclease action is phosphoramidite. The 2'-OMe-rA(Bz) phosphoramidite modification improves binding affinity to target sequences, increases hybridization specificity, and lowers off-target effects, enhancing oligonucleotide properties. It also enables better sequence-specific recognition by proteins. 2'-OMe-rA(Bz) Phosphoramidite supports a variety of nucleic acid-based applications such as antisense oligonucleotides, siRNA, gene design, and genome editing, including CRISPR-cas9 gRNA. Overall, 2'-OMe-rA(Bz) Phosphoramidite is a reliable solution for improving oligonucleotide stability and functionality, suitable for various research and therapeutic development applications.